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J Surg Res ; Fifty solar PV companies already gone in as subsidies end. Motility disorders of the upper gastrointestinal tract in the intensive care unit: Organisation or lack of it! Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: Consider the depth of the water in the North Atlantic, and in the Pacific, and in the Tasman.
B. Nutritional assessment
Running Out of Veins: This series will provide nutrition support professionals with current and cutting-edge information in the field of nutrition support, clinical nutrition, and metabolism. Each webinar rebroadcast in the series is accredited separately. The eLearning Center is accessible from any internet connection at www. Any credit not claimed by the deadline of April 15, will not be entered into the CPE monitor system.
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The following individuals in the educational process have one or more relationships with commercial interests to disclose. Conflict resolved through peer review methodology. Conflict resolved through altering the topic so that it does not include practice recommendations, but addresses only the evidence-based science. This is the paper cited by Woo: Posted by Peter at Tuesday, July 24, No comments: Insulin makes you hungry 1.
If you want to think about the central effects of insulin you could do a great deal worse than working through this paper: Brain insulin controls adipose tissue lipolysis and lipogenesis It is jammed full of exquisite quotes: Thus, at the doses administered, brain insulin infusion inhibited lipolysis to a similar extent as that achieved with peripheral hyperinsulinemia" Here it is in pictures. What does a CNS infusion of insulin do to lipolysis, at what are purported to be physiological dose rates?
Obviously, it does exactly what peripheral insulin does, but using minuscule amounts; it suppresses lipolysis: Posted by Peter at Tuesday, July 24, 3 comments: Sunday, July 22, Butter gives you fatty liver! This paper is an absolute gem: It contains no trace of understanding in its entirety, but the numbers in the results are fascinating.
How do we sum it up? If you pay people to over eat kcal per day for three weeks they gain weight and they gain liver fat. Posted by Peter at Sunday, July 22, 14 comments: Butter gives you fatty liver! Tuesday, July 17, Oops. OMG, just seen how many comments are awaiting moderation now I'm back to occasional posting.
I'll see what I can do, if desperate I'll just delete the spam and hit post for them all. Apologies for the inattention over the past few weeks Posted by Peter at Tuesday, July 17, No comments: Woo had a bit of a rant about acipimox.
Here's my simplified idea. I've been interested in acipimox, in a round about sort of a way, for a very long time. To me, the core fascination is that it is not only an effective suppressor of lipolysis, but it is pretty well weight-neutral and it most certainly does not result in weight gain. Which, you have to admit, is interesting. How can this be? I feel something of a clue can be found in the studies using a similar drug, nicotinic acid. Both drugs effectively suppress plasma free fatty acids via the same receptor but the neatest study happens use nicotinic acid.
People may recall that I posted about the role of FFAs in the secretion of insulin as demonstrated by an isolated rodent pancreatic preparation, some time ago.
The core concept here is that insulin secretion is dependent on the chain length and saturation of the FFAs used for perfusing the pancreas along with the glucose. This phenomenon appears to be well appreciated by the authors of this next paper same research group: Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans So what happens to in-tact humans when you fast them for 24 hours to raise FFAs and then bolus them with intravenous glucose?
Or fast them, artificially drop their FFAs with nicotinic acid, and then bolus them with glucose? This is what happens: Posted by Peter at Tuesday, July 17, 8 comments: Monday, May 28, Speculation on the effect of subcutaneous adipocytes implanted in to the mesentery of mice.
Taking a piece of subcutaneous fat from a sacrificed mouse and implanting in to the mesentery of a recipient mouse causes weight loss in the recipient , starting once the surgery has healed. We know that healing takes something just over six weeks: Posted by Peter at Monday, May 28, 6 comments: Speculation on the effect of subcutaneous adipocytes implanted in to the mesentery of mice.
Sunday, May 20, Guddling in the dark for a respiratory quotient 2. Multiple papers have values that don't make sense, which is an issue making me doubt my sanity and is damaging to my personal extensive set of confirmation biases. They also produce basic contradictions of the physiology of the oxidation of glucose vs the oxidation of fatty acids.
But now I think I can go back and explain much of the peculiarity in this image from Kahn's group, the one which triggered this previous post. Two sets of mice, on the same chow, having sustained differences in RQ, in a way I couldn't understand: Posted by Peter at Sunday, May 20, 12 comments: Guddling in the dark for a respiratory quotient 2.
I picked up this paper via Face-ache so cannot recall to whom I should credit for the find. The post is also highly speculative. Higher h Respiratory Quotient and Higher Spontaneous Physical Activity in Nighttime Eaters It's worth noting that the difference is small but probably biologically significant. Statistically p is less than 0. Before we think about it we need some background.
That comes from the same group in an earlier paper: Posted by Peter at Saturday, May 12, 21 comments: Nighttime Eaters have an elevated RQ on a given macro ratio diet. Friday, April 13, AHA approved egg! One of the full size chickens miss-fired yesterday and produced this minute egg: Posted by Peter at Friday, April 13, 19 comments: Monday, April 09, Pasta for weight loss.
This paper hit T'internet recently and has been cited all over the place: Effect of pasta in the context of low-glycaemic index dietary patterns on body weight and markers of adiposity: I've greyed it out so no-one is tempted to read it in full, the flavour is all you need: All authors have completed the Unified Competing Interest form available on request from the corresponding author and declare: His wife is an employee of Unilever Canada.
This a BMJ publication. The critical aspect to me is the publication date. Was it April the first? It should have been, except April the first this year was Easter Sunday. Not even at BMJ do they hit the "publish" button on a Sunday morning. Easter Monday appears fair game and someone at BMJ appears to have been at work to hit said publish button on April the 2nd.
Ah, the twists of fate produced by the lunacy of the movement of Easter through the calendar. I think someone at the BMJ may have a sense of humour. Reading the conflict of interest statement, I wonder if the authors do too and whether there was some collusion in the choice of publication date.
Otherwise it's not funny. Posted by Peter at Monday, April 09, 13 comments: Pasta for weight loss. Wednesday, March 21, Guddling in the dark for a respiratory quotient. How can two groups of mice, on exactly the same chow, have different 24h averaged RQs, p less than 0.
Posted by Peter at Wednesday, March 21, 17 comments: Guddling in the dark. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree.
I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds.
I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them. View my complete profile. Organisation or lack of it! If they're numbered within a similar label, start with 1. I might change it to the previous week if I ever get to time to put up enough posts in a week to justify it. That seems to be the best I can do within the limits of this blogging software! It's all over now Between countries 1 Cholesterol ratios through the looking glass 1 Cholesterol ratios: Do chylomicrons clog your arteries?
LCAT and rabbits 1 Cholesterol: LDL in Oslo 1 Cholesterol: More epidemiology 1 Cholesterol: Near miss in Edinburgh 1 Cholesterol: Peto seeing some light? What does it mean? African Beef Stew 1 Food: Lardo; the real thing 1 Food: Liver and bacon 1 Food: Liver; can you over do it?
Mutton or lamb in orange sauce 1 Food: Optimal ice cream 1 Food: Pork in green salsa and random dessert 1 Food: Recipe group 1 Food: You have coeliac disease 1 Gluten; thyroid and auto immunity 1 Gluten: Does coeliac disease require an infection?
Not your average plant toxin? Cornstarch vs ketones 1 Guddling in the dark 1 Guddling in the dark for a respiratory quotient 2 1 Guess the weight of the mouse competition 1 Gwyneth Paltrow has osteopaenia 1 Hazel eats butter 1 HbA1c and Familial Hypercholesterolaemia 1 HbA1c: Crack vs smack for a lower reading?
Part 2 1 Insulin: Should idiots be allowed to write the methods section of any "scientific" paper? What's your mimium requirement? They're just like mice! They're getting fat 1 Nissen on Niaspan 1 Normoglycaemia independent of insulin? Interleukin-6 and a tale of two or three studies 1 On phosphorylating AKT: Jebb 1 Paignton Zoo 1 Paleo and fructose 1 Palmitic acid and hyperglycaemia in diabetic heart failure 1 1 Palmitic acid based food vs olive oil or corn oil supplements 1 Palmitic acid: Eat fat 1 Peter eats vegetables 1 PharmAmorin 1 Physiological insulin resistance 1 1 Physiological insulin resistance 2 ; Dawn Phenomenon 1 Physiological insulin resistance 3 ; Clarification of FBG 1 Physiological insulin resistance 4 ; Alzheimers 1 Physiological insulin resistance 5 The wild type mice 1 Physiological insulin resistance 6 The Terminator 1 Physiological insulin resistance 7 and palmitic acid again 1 Physiological insulin resistance 8 Chewing the FAT 1 Physiological insulin resistance 9 Dolphins 1 Physiological insulin restisance 8 Guess what?
Superoxide 1 Protons Fasting 1 Protons Metformin 1 Protons Lactate 1 Protons Palmitoleate 1 Protons SCD1 knockout mice 1 Protons Linoleic acid in the hypothalamus 1 Protons The pancreas 1 Protons Zero fat 1 Protons Love your superoxide 1 Protons SCD1 and the bomb 1 Protons Physiological insulin resistance 1 Protons Physiological insulin resistance addendum 1 Protons Physiological insulin resistance addendum 2 1 Protons The linoleic acid fed mice 1 Protons Where is FeS cluster N-1a?
TFAM and behenic acid 1 Protons Back to N-1a and a nice quote 1 Protons Meet the glycerol 3 phosphate shuttle 1 Protons Aside to T cells 1 Protons 26 Chowdhury and Crabtree play with mitochondria 1 Protons 27 Physiological insulin resistance again 1 Protons 28 Protons so far 1 Protons 29 Uncoupling with fatty acids 1 Protons 30 Uncoupling and metabolic rate in insulin resistance 1 Protons 31 insulin induced theromgenesis in the Pima 1 Protons 32 Post obese insulin induced thermogenesis 1 Protons 33 The mtG3Pdh knockout mice 1 Protons 34 Rotenone 1 Protons 35 TFAM-KO revisited 1 Protons 36 Glycolysis to lactate 1 Protons 37 full glycerophosphate shuttle knockout mice 1 Protons 38 and ultra low fat once more 1 Protons 39 mtG3Pdh and lactate vs pyruvate 1 Protons 40 Living without the glycerophosphate shuttle 1 Protons 41 Metformin in the liver 1 Protons 42 Metformin as the next epilepsy drug?
Payday in Colorado 1 Saturated fat and fatty liver.